The 2012 S.League was the 17th season of the S-League, the top professional football league in Singapore. It is known as the Great Eastern-Yeo's S.League for sponsorship reasons.
Tampines Rovers won their fourth title, finishing top of a 13-team league.
Etoile FC withdrew their participation in the league to concentrate on grassroots football and youth development. DPMM FC have re-entered the league, coming back since they were suspended by FIFA in the 2009 campaign. Harimau Muda of Malaysia have also entered the fray.
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