The Colorado Rockies' 2012 season was the franchise's 20th in Major League Baseball. It involved the Rockies' 18th season of playing their home games at Coors Field.
|- bgcolor="ffbbbb" |- align="center" bgcolor="bbffbb" | 1 || April 6 || @ Astros || 5–3 || Guthrie (1–0) || Rodriguez (0–1) || Betancourt (1) || 43,464 || 1–0 |- align="center" bgcolor="ffbbbb" | 2 || April 7 || @ Astros || 7–3 || Harrell (1–0) || Moyer (0–1) || || 23,962 || 1–1 |- align="center" bgcolor="ffbbbb" | 3 || April 8 || @ Astros || 3–2 || López (1–0) || Brothers (0–1) || Myers (1) || 14,195 || 1–2 |- align="center" bgcolor="ffbbbb" | 4 || April 9 || Giants || 7–0 || Zito (1–0) || ChacÃÂn (0–1) || || 49,282 || 1–3 |- align="center" bgcolor="bbffbb" | 5 || April 11 || Giants || 17–8 || Reynolds (1–0) || Mota (0–1) || Chatwood (1) || 30,337 || 2–3 |- align="center" bgcolor="ffbbbb" | 6 || April 12 || Giants || 4–2 || Bumgarner (1–1) || Moyer (0–2) || Wilson (1) || 25,860 || 2–4 |- align="center" bgcolor="bbffbb" | 7 || April 13 || Diamondbacks || 7–6 || Brothers (1–1) || Shaw (0–1) || Betancourt (2) || 30,642 || 3–4 |- align="center" bgcolor="bbffbb" | 8 || April 14 || Diamondbacks || 8–7 || Chatwood (1–0) || Putz (0–1) || || 29,856 || 4–4 |- align="center" bgcolor="ffbbbb" | 9 || April 15 || Diamondbacks || 5–2 || Cahill (1–0) || Pomeranz (0–1) || Shaw (2) || 26,952 || 4–5 |- align="center" bgcolor="ffbbbb" | 10 || April 16 || Padres || 7–1 || Luebke (1–1) || Guthrie (1–1) || || 21,547 || 4–6 |- align="center" bgcolor="bbffbb" | 11 || April 17 || Padres || 5–3 || Moyer (1–2) || Bass (0–2) || Betancourt (3) || 24,525 || 5–6 |- align="center" bgcolor="bbffbb" | 12 || April 18 || Padres || 8–4 || Nicasio (1–0) || Richard (1–1) || || 24,762 || 6–6 |- align="center" bgcolor="bbffbb" | 13 || April 20 || @ Brewers || 4–3 || Belisle (1–0) || Axford (0–1) || Betancourt (4) || 39,188 || 7–6 |- align="center" bgcolor="ffbbbb" | 14 || April 21 || @ Brewers || 9–4 || Veras (2–0) || Rogers (0–1) || || 43,565 || 7–7 |- align="center" bgcolor="bbffbb" | 15 || April 22 || @ Brewers || 4–1 || Guthrie (2–1) || RodrÃÂguez (0–2) || Betancourt (5) || 42,611 || 8–7 |- align="center" bgcolor="bbbbbb" | – || April 23 || @ Pirates || colspan=6 | Postponed (rain) <small>Rescheduled for April 25</small> |- align="center" bgcolor="ffbbbb" | 16 || April 24 || @ Pirates || 5–4 || Watson (1–0) || Belisle (1–1) || Hanrahan (3) || 10,484 || 8–8 |- align="center" bgcolor="bbffbb" | 17 || April 25 || @ Pirates || 2–1 || Reynolds (2–0) || Resop (0–2) || Betancourt (6) || || 9–8 |- align="center" bgcolor="ffbbbb" | 18 || April 25 || @ Pirates || 5–1 || Morton (1–1) || ChacÃÂn (0–2) || || 15,218 || 9–9 |- align="center" bgcolor="bbffbb" | 19 || April 27 || Mets || 18–9 || Reynolds (3–0) || Acosta (0–1) || || 35,103 || 10–9 |- align="center" bgcolor="ffbbbb" | 20 || April 28 || Mets || 7–5 || Gee (2–2) || Moscoso (0–1) || Francisco (5) || 38,798 || 10–10 |- align="center" bgcolor="ffbbbb" | 21 || April 29 || Mets || 6–5 <small>(11)</small> || Francisco (1–1) || Belisle (1–2) || RamÃÂrez (1) || 36,690 || 10–11 |- align="center" bgcolor="bbffbb" | 22 || April 30 || Dodgers || 6–2 || Nicasio (2–0) || Harang (1–2) || || 25,227 || 11–11 |-
|- bgcolor="ffbbbb" |- align="center" bgcolor="ffbbbb" | 23 || May 1 || Dodgers || 7–6 || Lilly (3–0) || ChacÃÂn (0–3) || Guerra (8) || 26,211 || 11–12 |- align="center" bgcolor="bbffbb" | 24 || May 2 || Dodgers || 8–5 || Betancourt (1–0) || Wright (1–1) || || 30,276 || 12–12 |- align="center" bgcolor="ffbbbb" | 25 || May 4 || Braves || 9–8 <small>(11)</small> || Durbin (2–0) || Escalona (0–1) || Kimbrel (9) || 33,184 || 12–13 |- align="center" bgcolor="ffbbbb" | 26 || May 5 || Braves || 13–9 || MartÃÂnez (2–0) || Rogers (0–2) || Hernández (1) || 40,013 || 12–14 |- align="center" bgcolor="ffbbbb" | 27 || May 6 || Braves || 7–2 || Beachy (3–1) || Nicasio (2–1) || MartÃÂnez (1) || 45,330 || 12–15 |- align="center" bgcolor="ffbbbb" | 28 || May 7 || @ Padres || 3–2 || Vólquez (1–2) || Pomeranz (0–2) || Thayer (1) || 15,895 || 12–16 |- align="center" bgcolor="ffbbbb" | 29 || May 8 || @ Padres || 3–1 || Suppan (2–0) || White (0–1) || Thayer (2) || 17,478 || 12–17 |- align="center" bgcolor="bbffbb" | 30 || May 9 || @ Padres || 6–2 || Friedrich (1–0) || Bass (1–4) || || 20,059 || 13–17 |- align="center" bgcolor="ffbbbb" | 31 || May 11 || @ Dodgers || 7–3 || Capuano (5–0) || Moyer (1–3) || || 35,591 || 13–18 |- align="center" bgcolor="ffbbbb" | 32 || May 12 || @ Dodgers || 2–1 || Harang (2–2) || Outman (0–1) || Jansen (3) || 33,735 || 13–19 |- align="center" bgcolor="ffbbbb" | 33 || May 13 || @ Dodgers || 11–5 || Lilly (5–0) || White (0–2) || || 49,124 || 13–20 |- align="center" bgcolor="ffbbbb" | 34 || May 14 || @ Giants || 3–2 || Romo (2–0) || Brothers (1–2) || Casilla (8) || 41,254 || 13–21 |- align="center" bgcolor="bbffbb" | 35 || May 15 || @ Giants || 5–4 || Brothers (2–2) || Casilla (0–2) || Betancourt (7) || 41,332 || 14–21 |- align="center" bgcolor="bbffbb" | 36 || May 16 || Diamondbacks || 6–1 || Moyer (2–3) || Corbin (2–2) || || 32,162 || 15–21 |- align="center" bgcolor="ffbbbb" | 37 || May 17 || Diamondbacks || 9–7 || Ziegler (2–1) || Betancourt (1–1) || Putz (7) || 32,035 || 15–22 |- align="center" bgcolor="ffbbbb" | 38 || May 18 || Mariners || 4–0 || Millwood (2–4) || White (0–3) || || 34,887 || 15–23 |- align="center" bgcolor="ffbbbb" | 39 || May 19 || Mariners || 10–3 || Vargas (5–3) || Friedrich (1–1) || || 30,784 || 15–24 |- align="center" bgcolor="ffbbbb" | 40 || May 20 || Mariners || 6–4 || Beavan (2–4) || Guthrie (2–2) || || 36,662 || 15–25 |- align="center" bgcolor="ffbbbb" | 41 || May 21 || @ Marlins || 7–4 || Buehrle (4–4) || Moyer (2–4) || Bell (6) || 25,155 || 15–26 |- align="center" bgcolor="ffbbbb" | 42 || May 22 || @ Marlins || 7–6 || Nolasco (5–2) || Nicasio (2–2) || Bell (7) || 22,242 || 15–27 |- align="center" bgcolor="bbffbb" | 43 || May 23 || @ Marlins || 8–4 || White (1–3) || Zambrano (2–3) || || 23,985 || 16–27 |- align="center" bgcolor="bbffbb" | 44 || May 25 || @ Reds || 6–3 || Friedrich (2–1) || Cueto (5–2) || Betancourt (8) || 29,597 || 17–27 |- align="center" bgcolor="ffbbbb" | 45 || May 26 || @ Reds || 10–3 || Hoover (1–0) || Guthrie (2–3) || || 35,314 || 17–28 |- align="center" bgcolor="ffbbbb" | 46 || May 27 || @ Reds || 7–5 || Latos (4–2) || Moyer (2–5) || Chapman (3) || 29,368 || 17–29 |- align="center" bgcolor="bbffbb" | 47 || May 28 || Astros || 9–7 || Belisle (2–2) || Rodriguez (1–5) || Betancourt (9) || 34,546 || 18–29 |- align="center" bgcolor="bbffbb" | 48 || May 28 || Astros || 7–6 <small>(10)</small> || Roenicke (1–0) || Myers (0–2) || || 35,786 || 19–29 |- align="center" bgcolor="bbffbb" | 49 || May 30 || Astros || 13–5 || Friedrich (3–1) || Harrell (4–4) || || 28,102 || 20–29 |- align="center" bgcolor="bbffbb" | 50 || May 31 || Astros || 11–5 || Guthrie (3–3) || Norris (5–2) || || 31,799 || 21–29 |-
|- bgcolor="ffbbbb" |- align="center" bgcolor="bbffbb" | 51 || June 1 || Dodgers || 13–3 || Ottavino (1–0) || Capuano (7–2) || || 36,795 || 22–29 |- align="center" bgcolor="ffbbbb" | 52 || June 2 || Dodgers || 6–2 || Harang (4–3) || Nicasio (2–3) || || 36,175 || 22–30 |- align="center" bgcolor="bbffbb" | 53 || June 3 || Dodgers || 3–2 || White (2–3) || Eovaldi (0–2) || Betancourt (10) || 35,353 || 23–30 |- align="center" bgcolor="bbffbb" | 54 || June 5 || @ Diamondbacks || 4–0 || Friedrich (4–1) || Saunders (3–4) || || 22,881 || 24–30 |- align="center" bgcolor="ffbbbb" | 55 || June 6 || @ Diamondbacks || 10–0 || Kennedy (5–5) || Guthrie (3–4) || || 22,322 || 24–31 |- align="center" bgcolor="ffbbbb" | 56 || June 7 || @ Diamondbacks || 6–1 || Miley (7–2) || Outman (0–2) || || 23,069 || 24–32 |- align="center" bgcolor="ffbbbb" | 57 || June 8 || Angels || 7–2 || Wilson (7–4) || White (2–4) || || 41,814 || 24–33 |- align="center" bgcolor="ffbbbb" | 58 || June 9 || Angels || 11–5 || Haren (4–6) || Francis (0–1) || || 37,801 || 24–34 |- align="center" bgcolor="ffbbbb" | 59 || June 10 || Angels || 10–8 || Santana (3–7) || Friedrich (4–2) || Downs (6) || 37,722 || 24–35 |- align="center" bgcolor="ffbbbb" | 60 || June 12 || Athletics || 8–5 || Colón (6–6) || Guthrie (3–5) || Cook (1) || 33,635 || 24–36 |- align="center" bgcolor="ffbbbb" | 61 || June 13 || Athletics || 10–8 || Blevins (1–0) || Betancourt (1–2) || Cook (2) || 32,155 || 24–37 |- align="center" bgcolor="ffbbbb" | 62 || June 14 || Athletics || 8–2 || Parker (3–3) || White (2–5) || || 32,527 || 24–38 |- align="center" bgcolor="bbffbb" | 63 || June 15 || @ Tigers || 12–4 <small>(10)</small> || Belisle (3–2) || Valverde (3–2) || || 41,878 || 25–38 |- align="center" bgcolor="ffbbbb" | 64 || June 16 || @ Tigers || 4–1 || Fister (1–3) || Friedrich (4–3) || || 41,800 || 25–39 |- align="center" bgcolor="ffbbbb" | 65 || June 17 || @ Tigers || 5–0 || Scherzer (6–4) || Guthrie (3–6) || || 40,619 || 25–40 |- align="center" bgcolor="ffbbbb" | 66 || June 19 || @ Phillies || 7–2 || Hamels (10–3) || Outman (0–3) || || 44,329 || 25–41 |- align="center" bgcolor="ffbbbb" | 67 || June 20 || @ Phillies || 7–6 || Papelbon (1–2) || Betancourt (1–3) || || 43,729 || 25–42 |- align="center" bgcolor="bbffbb" | 68 || June 21 || @ Phillies || 4–1 || Roenicke (2–0) || Worley (3–4) || Betancourt (11) || 43,805 || 26–42 |- align="center" bgcolor="ffbbbb" | 69 || June 22 || @ Rangers || 4–1 || Oswalt (1–0) || Friedrich (4–4) || Nathan (16) || 46,964 || 26–43 |- align="center" bgcolor="bbffbb" | 70 || June 23 || @ Rangers || 11–7 || Brothers (3–2) || Lewis (6–6) || || 42,516 || 27–43 |- align="center" bgcolor="ffbbbb" | 71 || June 24 || @ Rangers || 4–2 || Harrison (10–3) || White (2–6) || || 45,407 || 27–44 |- align="center" bgcolor="bbffbb" | 72 || June 25 || Nationals || 4–2 || Roenicke (3–0) || Strasburg (9–2) || Betancourt (12) || 40,177 || 28–44 |- align="center" bgcolor="ffbbbb" | 73 || June 26 || Nationals || 12–5 || Gonzalez (10–3) || Friedrich (4–5) || || 36,110 || 28–45 |- align="center" bgcolor="ffbbbb" | 74 || June 27 || Nationals || 11–5 || Zimmermann (4–6) || Cabrera (0–1) || || 36,045 || 28–46 |- align="center" bgcolor="bbffbb" | 75 || June 28 || Nationals || 11–10 <small>(11)</small> || Ottavino (2–0) || Stammen (3–1) || || 33,957 || 29–46 |- align="center" bgcolor="bbffbb" | 76 || June 29 || Padres || 10–2 || Francis (1–1) || Marquis (3–8) || || 42,785 || 30–46 |- align="center" bgcolor="ffbbbb" | 77 || June 30 || Padres || 8–4 || Vólquez (5–7) || Guthrie (3–7) || || 48,169 || 30–47 |-
|- bgcolor="ffbbbb" |- align="center" bgcolor="ffbbbb" | 78 || July 1 || Padres || 2–0 || Wells (1–1) || Pomeranz (0–3) || Street (12) || 31,829 || 30–48 |- align="center" bgcolor="ffbbbb" | 79 || July 2 || @ Cardinals || 9–3 || Lohse (8–2) || Chatwood (1–1) || || 39,456 || 30–49 |- align="center" bgcolor="bbffbb" | 80 || July 3 || @ Cardinals || 3–2 || Francis (2–1) || Kelly (1–1) || Betancourt (13) || 41,701 || 31–49 |- align="center" bgcolor="ffbbbb" | 81 || July 4 || @ Cardinals || 4–1 || Wainwright (7–8) || Guthrie (3–8) || Motte (18) || 42,338 || 31–50 |- align="center" bgcolor="ffbbbb" | 82 || July 5 || @ Cardinals || 6–2 || Lynn (11–4) || Friedrich (4–6) || Motte (19) || 41,751 || 31–51 |- align="center" bgcolor="bbffbb" | 83 || July 6 || @ Nationals || 5–1 || Pomeranz (1–3) || Strasburg (9–4) || Betancourt (14) || 28,951 || 32–51 |- align="center" bgcolor="ffbbbb" | 84 || July 7 || @ Nationals || 4–1 || Gonzalez (12–3) || Francis (2–2) || Clippard (14) || 28,032 || 32–52 |- align="center" bgcolor="bbffbb" | 85 || July 8 || @ Nationals || 4–3 || Brothers (4–2) || Clippard (2–3) || Betancourt (15) || 25,125 || 33–52 |- align="center" bgcolor="bbffbb" | 86 || July 13 || Phillies || 6–2 || Friedrich (5–6) || Lee (1–6) || || 33,346 || 34–52 |- align="center" bgcolor="ffbbbb" | 87 || July 14 || Phillies || 8–5 || Worley (5–5) || Guthrie (3–9) || Papelbon (19) || 35,151 || 34–53 |- align="center" bgcolor="ffbbbb" | 88 || July 15 || Phillies || 5–1 || Hamels (11–4) || Pomeranz (1–4) || || 25,685 || 34–54 |- align="center" bgcolor="bbffbb" | 89 || July 16 || Pirates || 5–4 || Brothers (5–2) || Grilli (1–3) || || 36,907 || 35–54 |- align="center" bgcolor="ffbbbb" | 90 || July 17 || Pirates || 6–2 || Bédard (5–10) || Friedrich (5–7) || Hanrahan (25) || 42,574 || 35–55 |- align="center" bgcolor="ffbbbb" | 91 || July 18 || Pirates || 9–6 || McDonald (10–3) || Reynolds (3–1) || Hanrahan (26) || 30,842 || 35–56 |- align="center" bgcolor="ffbbbb" | 92 || July 20 || @ Padres || 9–5 || Marquis (5–9) || Pomeranz (1–5) || || 25,507 || 35–57 |- align="center" bgcolor="bbffbb" | 93 || July 21 || @ Padres || 8–6 <small>(12)</small> || Torres (1–0) || Thatcher (0–3) || Betancourt (16) || 37,174 || 36–57 |- align="center" bgcolor="ffbbbb" | 94 || July 22 || @ Padres || 3–2 || Thayer (2–2) || Ottavino (2–1) || Street (16) || 25,198 || 36–58 |- align="center" bgcolor="ffbbbb" | 95 || July 23 || @ Diamondbacks || 6–3 || Kennedy (8–8) || Sánchez (1–7) || Putz (18) || 20,056 || 36–59 |- align="center" bgcolor="ffbbbb" | 96 || July 24 || @ Diamondbacks || 6–2 || Saunders (5–6) || Cabrera (0–2) || || 20,432 || 36–60 |- align="center" bgcolor="bbffbb" | 97 || July 25 || @ Diamondbacks || 4–2 || Francis (3–2) || Cahill (8–9) || Betancourt (17) || 23,385 || 37–60 |- align="center" bgcolor="ffbbbb" | 98 || July 27 || Reds || 3–0 || Arroyo (6–6) || Pomeranz (1–6) || Chapman (20) || 38,214 || 37–61 |- align="center" bgcolor="ffbbbb" | 99 || July 28 || Reds || 9–7 || Cueto (13–5) || Friedrich (5–8) || Chapman (21) || 42,826 || 37–62 |- align="center" bgcolor="ffbbbb" | 100 || July 29 || Reds || 7–2 || Latos (9–3) || Sánchez (1–8) || || 29,430 || 37–63 |- align="center" bgcolor="ffbbbb" | 101 || July 31 || Cardinals || 11–6 || Lohse (11–2) || Francis (3–3) || || 31,297 || 37–64 |-
|- bgcolor="ffbbbb" |- align="center" bgcolor="ffbbbb" | 102 || August 1 || Cardinals || 9–6 || Westbrook (10–8) || Belisle (3–3) || || 29,547 || 37–65 |- align="center" bgcolor="bbffbb" | 103 || August 2 || Cardinals || 8–2 || Brothers (6–2) || Salas (1–4) || || 29,659 || 38–65 |- align="center" bgcolor="ffbbbb" | 104 || August 3 || Giants || 16–4 || Vogelsong (9–5) || Sánchez (1–9) || || 30,176 || 38–66 |- align="center" bgcolor="ffbbbb" | 105 || August 4 || Giants || 11–6 || Bumgarner (12–6) || Francis (3–4) || || 35,242 || 38–67 |- align="center" bgcolor="ffbbbb" | 106 || August 5 || Giants || 8–3 || Lincecum (6–11) || Chatwood (1–2) || || 28,804 || 38–68 |- align="center" bgcolor="bbffbb" | 107 || August 6 || @ Dodgers || 2–0 || Ottavino (3–1) || Capuano (10–8) || Betancourt (18) || 32,659 || 39–68 |- align="center" bgcolor="bbffbb" | 108 || August 7 || @ Dodgers || 3–1 || Roenicke (4–0) || Harang (7–7) || Betancourt (19) || 55,024 || 40–68 |- align="center" bgcolor="ffbbbb" | 109 || August 8 || @ Dodgers || 6–4 || Billingsley (8–9) || Torres (1–1) || Jansen (22) || 37,084 || 40–69 |- align="center" bgcolor="bbffbb" | 110 || August 10 || @ Giants || 3–0 || Chatwood (2–2) || Lincecum (6–12) || Betancourt (20) || 41,729 || 41–69 |- align="center" bgcolor="ffbbbb" | 111 || August 11 || @ Giants || 9–3 || Cain (11–5) || Pomeranz (1–7) || || 42,483 || 41–70 |- align="center" bgcolor="ffbbbb" | 112 || August 12 || @ Giants || 9–6 || Hensley (4–3) || Belisle (3–4) || || 41,492 || 41–71 |- align="center" bgcolor="bbffbb" | 113 || August 13 || Brewers || 9–6 || Francis (4–4) || Fiers (6–5) || || 26,821 || 42–71 |- align="center" bgcolor="bbffbb" | 114 || August 14 || Brewers || 8–6 || Chatwood (3–2) || Wolf (3–9) || Betancourt (21) || 28,036 || 43–71 |- align="center" bgcolor="bbffbb" | 115 || August 15 || Brewers || 7–6 || Harris (1–0) || Henderson (0–2) || || 23,411 || 44–71 |- align="center" bgcolor="bbffbb" | 116 || August 16 || Marlins || 5–3 || Ottavino (4–1) || Nolasco (9–12) || Betancourt (22) || 24,807 || 45–71 |- align="center" bgcolor="ffbbbb" | 117 || August 17 || Marlins || 6–5 || LeBlanc (2–2) || Roenicke (4–1) || Cishek (8) || 25,614 || 45–72 |- align="center" bgcolor="ffbbbb" | 118 || August 18 || Marlins || 6–5 || Eovaldi (4–8) || Chatwood (3–3) || Cishek (9) || 30,426 || 45–73 |- align="center" bgcolor="bbffbb" | 119 || August 19 || Marlins || 3–2 || Ottavino (5–1) || Johnson (7–10) || Betancourt (23) || 43,961 || 46–73 |- align="center" bgcolor="bbffbb" | 120 || August 20 || @ Mets || 3–1 || Brothers (7–2) || Edgin (1–1) || Betancourt (24) || 23,833 || 47–73 |- align="center" bgcolor="bbffbb" | 121 || August 21 || @ Mets || 6–2 || ChacÃÂn (1–3) || Young (3–7) || || 27,633 || 48–73 |- align="center" bgcolor="bbffbb" | 122 || August 22 || @ Mets || 5–2 || Torres (2–1) || RamÃÂrez (2–3) || Betancourt (25) || 22,204 || 49–73 |- align="center" bgcolor="bbffbb" | 123 || August 23 || @ Mets || 1–0 || Brothers (8–2) || Parnell (2–3) || Belisle (1) || 22,544 || 50–73 |- align="center" bgcolor="ffbbbb" | 124 || August 24 || @ Cubs || 5–3 || Russell (6–1) || Belisle (3–5) || Mármol (16) || 31,255 || 50–74 |- align="center" bgcolor="bbffbb" | 125 || August 25 || @ Cubs || 4–3 || Torres (3–1) || Corpas (0–1) || Betancourt (26) || 35,296 || 51–74 |- align="center" bgcolor="ffbbbb" | 126 || August 26 || @ Cubs || 5–0 <small>(8)</small> || Volstad (1–9) || ChacÃÂn (1–4) || Camp (2) || 32,346 || 51–75 |- align="center" bgcolor="bbffbb" | 127 || August 27 || Dodgers || 10–0 || Francis (5–4) || Beckett (5–12) || Belisle (2) || 30,148 || 52–75 |- align="center" bgcolor="bbffbb" | 128 || August 28 || Dodgers || 8–4 || Chatwood (4–3) || Capuano (11–10) || || 28,368 || 53–75 |- align="center" bgcolor="ffbbbb" | 129 || August 29 || Dodgers || 10–8 || Blanton (9–12) || Pomeranz (1–8) || Belisario (1) || 25,155 || 53–76 |- align="center" bgcolor="ffbbbb" | 130 || August 31 || Padres || 5–4 || Richard (12–12) || White (2–7) || Gregerson (3) || 27,366 || 53–77 |-
|- bgcolor="ffbbbb" |- align="center" bgcolor="bbffbb" | 131 || September 1 || Padres || 9–1 || ChacÃÂn (2–4) || Vólquez (9–10) || || 30,152 || 54–77 |- align="center" bgcolor="bbffbb" | 132 || September 2 || Padres || 11–10 || Moscoso (1–1) || Brach (1–4) || Betancourt (27) || 30,678 || 55–77 |- align="center" bgcolor="ffbbbb" | 133 || September 3 || @ Braves || 6–1 || Medlen (7–1) || Chatwood (4–4) || || 24,848 || 55–78 |- align="center" bgcolor="bbffbb" | 134 || September 4 || @ Braves || 6–0 || Torres (4–1) || Hanson (12–8) || || 16,686 || 56–78 |- align="center" bgcolor="ffbbbb" | 135 || September 5 || @ Braves || 1–0 || Minor (8–10) || White (2–8) || Kimbrel (33) || 16,714 || 56–79 |- align="center" bgcolor="ffbbbb" | 136 || September 6 || @ Braves || 1–0 || Hudson (14–5) || ChacÃÂn (2–5) || Kimbrel (34) || 19,313 || 56–80 |- align="center" bgcolor="ffbbbb" | 137 || September 7 || @ Phillies || 3–2 || Papelbon (4–6) || Harris (1–1) || || 42,028 || 56–81 |- align="center" bgcolor="bbbbbb" | – || September 8 || @ Phillies || colspan=6 | Postponed (rain) <small> Rescheduled for September 9</small> |- align="center" bgcolor="ffbbbb" | 138 || September 9 || @ Phillies || 3–2 || Papelbon (5–6) || Belisle (3–6) || || 41,813 || 56–82 |- align="center" bgcolor="ffbbbb" | 139 || September 9 || @ Phillies || 7–4 || Rosenberg (1–2) || Roenicke (4–2) || Papelbon (32) || 40,394 || 56–83 |- align="center" bgcolor="bbffbb" | 140 || September 10 || Giants || 6–5 || Moscoso (2–1) || Vogelsong (12–8) || Betancourt (28) || 25,817 || 57–83 |- align="center" bgcolor="ffbbbb" | 141 || September 11 || Giants || 9–8 || Kontos (2–1) || Torres (4–2) || López (7) || 26,631 || 57–84 |- align="center" bgcolor="ffbbbb" | 142 || September 12 || Giants || 8–3 || Lincecum (9–14) || Francis (5–5) || || 24,182 || 57–85 |- align="center" bgcolor="bbffbb" | 143 || September 14 || @ Padres || 7–4 || Moscoso (3–1) || Cashner (3–4) || Betancourt (29) || 25,018 || 58–85 |- align="center" bgcolor="ffbbbb" | 144 || September 15 || @ Padres || 4–3 || Kelly (2–1) || Pomeranz (1–9) || Gregerson (8) || 27,651 || 58–86 |- align="center" bgcolor="ffbbbb" | 145 || September 16 || @ Padres || 12–11 || Thatcher (1–4) || Belisle (3–7) || || 22,948 || 58–87 |- align="center" bgcolor="ffbbbb" | 146 || September 17 || @ Giants || 2–1 || Bumgarner (15–10) || Moscoso (3–2) || Romo (12) || 41,280 || 58–88 |- align="center" bgcolor="ffbbbb" | 147 || September 18 || @ Giants || 6–3 || Lincecum (10–14) || Francis (5–6) || || 41,718 || 58–89 |- align="center" bgcolor="ffbbbb" | 148 || September 19 || @ Giants || 7–1 || Cain (15–5) || Chatwood (4–5) || || 41,292 || 58–90 |- align="center" bgcolor="ffbbbb" | 149 || September 20 || @ Giants || 9–2 || Zito (13–8) || de la Rosa (0–1) || || 41,157 || 58–91 |- align="center" bgcolor="ffbbbb" | 150 || September 21 || Diamondbacks || 15–5 || Miley (16–10) || White (2–9) || || 42,359 || 58–92 |- align="center" bgcolor="ffbbbb" | 151 || September 22 || Diamondbacks || 8–7 || Bergesen (2–0) || Torres (4–3) || Putz (31) || 33,689 || 58–93 |- align="center" bgcolor="ffbbbb" | 152 || September 23 || Diamondbacks || 10–7 || Albers (3–1) || Belisle (3–8) || Putz (32) || 32,448 || 58–94 |- align="center" bgcolor="bbffbb" | 153 || September 24 || Diamondbacks || 4–2 || Chatwood (5–5) || Cahill (12–12) || Betancourt (30) || 22,277 || 59–94 |- align="center" bgcolor="bbffbb" | 154 || September 25 || Cubs || 10–5 <small>(7)</small> || Torres (5–3) || Rusin (1–3) || || 26,660 || 60–94 |- align="center" bgcolor="bbffbb" | 155 || September 26 || Cubs || 6–0 || Pomeranz (2–9) || Berken (0–2) || || 27,057 || 61–94 |- align="center" bgcolor="bbffbb" | 156 || September 27 || Cubs || 7–5 || ChacÃÂn (3–5) || Volstad (3–11) || Betancourt (31) || 30,288 || 62–94 |- align="center" bgcolor="ffbbbb" | 157 || September 28 || @ Dodgers || 8–0 || Kershaw (13–9) || Francis (5–7) || || 37,133 || 62–95 |- align="center" bgcolor="ffbbbb" | 158 || September 29 || @ Dodgers || 3–0 || Blanton (10–13) || Chatwood (5–6) || League (15) || 40,724 || 62–96 |- align="center" bgcolor="ffbbbb" | 159 || September 30 || @ Dodgers || 7–1 || Beckett (7–14) || de la Rosa (0–2) || || 35,607 || 62–97 |-
|- bgcolor="ffbbbb" |- align="center" bgcolor="bbffbb" | 160 || October 1 || @ Diamondbacks || 7–5 <small>(13)</small> || Outman (1–3) || Bergesen (2–1) || Roenicke (1) || 24,123 || 63–97 |- align="center" bgcolor="ffbbbb" | 161 || October 2 || @ Diamondbacks || 5–3 || Ziegler (6–1) || Betancourt (1–4) || || 22,466 || 63–98 |- align="center" bgcolor="bbffbb" | 162 || October 3 || @ Diamondbacks || 2–1 || Francis (6–7) || Kennedy (15–12) || Belisle (3) || 24,344 || 64–98 |-
Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in
Note: G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in
Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts
Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts
Note: G = Games pitched; W = Wins; L = Losses; SV = Saves; ERA = Earned run average; SO = Strikeouts
<small>LEAGUE CHAMPIONS: Asheville</small>