The 2012 Cal Poly Mustangs football team represented California Polytechnic State University, San Luis Obispo as member of the Big Sky Conference during the 2012 NCAA Division I FCS football season. Led by fourth-year head coach Tim Walsh, Cal Poly compiled an overall record of 9âÂÂ3 with a mark of 7âÂÂ1 in conference play, sharing the Big Sky title Eastern Washington and Montana State. The Mustangs received an at-large big to the NCAA Division I Football Championship, where after a first-round bye, they lost to Sam Houston State in the second round. The team played home games at Alex G. Spanos Stadium in San Luis Obispo, California.
The game against Eastern Washington, fellow Big Sky member, on November 3 was considered a non-conference game and had no effect on the Big Sky standings.