The 2012 CAF Confederation Cup knock-out stage matches took place in November 2012. The matchdays were: 2âÂÂ4 November (semifinals first leg), 9âÂÂ11 November (semifinals second leg), 16âÂÂ18 November (final first leg), 23âÂÂ25 December (final second leg).
All knock-out ties were decided over two legs, with aggregate goals used to determine the winner. If the sides were level on aggregate after the second leg, the away goals rule applied, and if still level, the tie proceeded directly to a penalty shootout (no extra time is played).
The knock-out stage featured four teams: the two group winners and the two group runners-up from the group stage. In the semi-finals, the group A winners played the group B runners-up, and the group B winners played the group A runners-up. In both ties, the group winners hosted the second leg at home.
AC Léopards won 2âÂÂ1 on aggregate and advanced to the 2012 CAF Confederation Cup Final.
2âÂÂ2 on aggregate. Djoliba won the penalty shootout and advanced to the 2012 CAF Confederation Cup Final.
AC Léopards won 4âÂÂ3 on aggregate.