The 2011 CAF Champions League knock-out stage matches took place between September and November 2011. The matchdays were: 30 SeptemberâÂÂ2 October (semifinals first leg), 14âÂÂ16 October (semifinals second leg), 4âÂÂ6 November (final first leg), 11âÂÂ13 November (final second leg).
All knock-out ties were decided over two legs, with aggregate goals used to determine the winner. If the sides were level on aggregate after the second leg, the away goals rule applied, and if still level, the tie proceeded directly to a penalty shootout (no extra time is played).
The knock-out stage featured four teams: the two group winners and the two group runners-up from the group stage. In the semi-finals, the group A winners played the group B runners-up, and the group B winners played the group A runners-up. In both ties, the group winners hosted the second leg at home.
Wydad AC won 1âÂÂ0 on aggregate and advanced to the 2011 CAF Champions League Final.
Espérance ST won 3âÂÂ0 on aggregate and advanced to the 2011 CAF Champions League Final.
Espérance ST won 1âÂÂ0 on aggregate.