The 2010 Western Illinois Leathernecks football team represented Western Illinois University as a member of the Missouri Valley Football Conference (MFVC) during the 2010 NCAA Division I FCS football season. Led by third-year head coach Mark Hendrickson, the Leathernecks compiled an overall record of 8âÂÂ5 overall with mark of 5âÂÂ3 in conference play, placing second in the MVFC. Western Illinois received an at-large bid to the NCAA Division I Football Championship playoffs, where the Leathernecks defeated Coastal Carolina in the first round before losing to Appalachian State in the second round. The team played home games at Hanson Field in Macomb, Illinois.