2010 Regional League Division 2 Bangkok Metropolitan Region is the 2nd season of the League competition since its establishment in 2009. It is in the third tier of the Thai football league system.
The league has been expanded from 10 clubs in 2009 to 13 clubs this season. The league winners and runners up will qualify for the 2010 Regional League Division 2 championship stage.
Raj Pracha-Nonthaburi were promoted to the 2010 Thai Division 1 League after winning the 2009 Regional League Division 2 championship pool.
Thai Airways-Look Isan were relegated from the 2009 Thai Division 1 League after finishing the season in 15th place.
Thai Summit Samut Prakan and Rose Asia Pathum Thani re-located from the Regional League Central-East Division 2009
Nonthaburi and North Bangkok College joined the newly expanded league setup.
Sarawitaya dropped out of the league at the end of the 2009 campaign.