The 2010 Oklahoma Sooners baseball team represented the University of Oklahoma in the 2010 NCAA Division I baseball season. The Sooners played their home games at L. Dale Mitchell Baseball Park, and played as part of the Big 12 Conference. The team was coached by Sunny Golloway in his sixth season as head coach at Oklahoma.
The Sooners reached the College World Series, their tenth appearance in Omaha, where they finished tied for 5th place after a win against eventual champion South Carolina and losses to Clemson and South Carolina.