The 2010 Monza Superbike World Championship round was the fifth round of the 2010 Superbike World Championship season. It took place on the weekend of May 7–9, 2010 at the Autodromo Nazionale Monza located in Monza, Italy.
Both Roberto Lacalendola and Philippe Thiriet was disqualified post-race after failing to obey a ride through the entire race. Maxime Berger, Davide Giugliano, Eddi La Marra, and Dominic Lammert got 20-second time penalty post-race.