The 2010 Knoxville Challenger was a professional tennis tournament played on outdoor hard courts. It was the seventh edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Knoxville, Tennessee, United States between 8 and 14 November 2010.
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Kei Nishikori def. Robert Kendrick, 6âÂÂ1, 6âÂÂ4
Rik de Voest / Izak van der Merwe def. Alex Bogomolov Jr. / Alex Kuznetsov, 6âÂÂ1, 6âÂÂ4