The 2010 Federation Cup was the 32nd season of the Indian Federation Cup. The qualifiers commenced from 14 September. Eight teams battled it out for a place in the quarterfinal round and had been divided into two groups.
The cup winner were guaranteed a place in the 2011 AFC Cup.
The winner from each Zone qualified for the quarterfinal round which were held from 21 September.
|- !colspan="3"|Zone A Round 1
|- !colspan="3"|Final Play-off
|- !colspan="3"|Zone B Round 1
|- !colspan="3"|Final Play-off
The two qualifiers from the preliminary knock-out round joined the 14 I-League teams, who had been divided into four groups.
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|- !colspan="3"|Semi-final 1
|- !colspan="3"|Semi-final 2
|- !colspan="3"|The Final
Top scorers as of 29 September 2010.