The 2010 Conference USA baseball tournament was the 2010 postseason college baseball championship of the NCAA Division I Conference USA, held at Cougar Field in Houston, Texas, from May 26–May 30, 2010. Southern Miss won the tournament and received Conference USA's automatic bid to the 2010 NCAA Division I baseball tournament.
The tournament format changed from that which had been used since the 2000 tournament. It consisted of six teams split into two three-team pods. Each team played a total of three preliminary games, two against its podmates and one against a team from the opposite pod. The team with the best record in each pod going advanced to a single-game final.
<small><sup>â </sup> - Winner of the tournament and received an automatic bid to the NCAA tournament.<br/> <sup>#</sup> - Received an at-large bid to the NCAA tournament.</small>
(*)Denotes Unanimous Selection