The last four stages of the 2008 Copa Santander Libertadores are the knockout stages: the Round of 16, the Quarterfinals, the Semifinals, and the Finals.
The remaining stages of the tournament constitute a single-elimination tournament. In each stage, the teams will play an opponent in a two-legged tie on a home-away basis. Each team will earn three points for a win, one point for a draw, and zero points for a loss. The team with the most points at the end of each tie will advance.
The following criteria will be used for breaking ties on points:
The 16 qualified teams in the knockout round will be seeded according to their results in the group stage. The top teams from each group are seeded 1âÂÂ8, with the team with the most points as seed 1 and the team with the least as seed 8. The second-best teams from each group are seeded 9âÂÂ16, with the team with the most points as seed 9 and the team with the least as seed 16. Teams with a higher seed will play the second leg of each tie at home.
The Round of 16 was played between April 29 and 30, and May 1, 6, and 8. Team #1 played the second leg at home.
Fluminense advanced 6âÂÂ0 on points.
LDU Quito 3âÂÂ3 Estudiantes on points. LDU Quito advanced on better goal difference (+1).
Atlas advanced 4âÂÂ1 on points.
Boca Juniors advanced 6âÂÂ0 on points.
América 3âÂÂ3 Flamengo on points. América advanced on better goal difference (+1).
São Paulo advanced 4âÂÂ1 on points.
San Lorenzo advanced 4âÂÂ1 on points.
Santos advanced 6âÂÂ0 on points.
The Quarterfinals were played on May 14, 15, and May 21 and 22. Team #1 played the second leg at home.
Boca Juniors advanced 4âÂÂ1 on points.
Fluminense and São Paulo tied 3âÂÂ3 on points. Fluminense advanced on goal difference (+1).
LDU Quito and San Lorenzo tied 2âÂÂ2 on points, and tied 0 on goal difference. LDU Quito advanced 5âÂÂ3 on penalties.
América and Santos tied 3âÂÂ3 on points. América advanced on goal difference (+1).
The Semifinals were played between May 27, 28, and June 3, 4. Team #1 played the second leg at home.
LDU Quito 2âÂÂ2 América on points. LDU Quito advanced on away goals.
Fluminense advanced 4âÂÂ1 on points.