The First Stage of the 2008 Copa Santander Libertadores began on January 29 and ended on February 12. Twelve teams qualified directly on this stage.
Team #1 played the second leg at home.
Lanús and Olmedo tied 3âÂÂ3 on points. Lanús advanced on goal difference.
Cruzeiro advanced 6âÂÂ0 on points.
Mineros de Guayana and Arsenal tied 3âÂÂ3 on points. Arsenal advanced on goal difference.
La Paz and Atlas tied 3âÂÂ3 on points. Atlas advanced on goal difference.
Cienciano advanced 4âÂÂ1 on points.
Boyacá Chicó and Audax Italiano tied 3âÂÂ3 on points. Audax Italiano advanced on away goals.