The Colorado Rockies' 2008 season was the team's 16th season overall. The Rockies attempted to repeat their previous season's success after making it to the World Series; however, they ended up finishing third place in the National League West with a record of 74-88. The Rockies drew 2,650,218 fans for the season, their highest total since 2002. The average home attendance was 33,127 fans.
Likely the most memorable game of the year was against the San Diego Padres on April 17, as it went 22 innings before Troy Tulowitzki drove in the winning run. It is the longest Rockies game in franchise history and (as of ) the longest game of the 21st century.
|- bgcolor="#bbbbbb" | â || March 31 || @ Cardinals ||colspan=6|Postponed (rain) <small>Rescheduled for April 1</small> |-
|- align="center" bgcolor="bbffbb" | 1 || April 1 || @ Cardinals || 2–1 || Buchholz (1–0) || Franklin (0–1) || Corpas (1) || 45,996 || 1–0 |- align="center" bgcolor="ffbbbb" | 2 || April 2 || @ Cardinals || 8–3 || Wellemeyer (1–0) || Cook (0–1) || || 39,915 || 1–1 |- align="center" bgcolor="ffbbbb" | 3 || April 3 || @ Cardinals || 3–0 || Thompson (1–0) || Jiménez (0–1) || Isringhausen (1) || 33,748 || 1–2 |- align="center" bgcolor="ffbbbb" | 4 || April 4 || Diamondbacks || 8–1 || Owings (1–0) || Redman (0–1) || || 49,233 || 1–3 |- align="center" bgcolor="ffbbbb" | 5 || April 5 || Diamondbacks || 7–2 || Webb (2–0) || Francis (0–1) || || 43,124 || 1–4 |- align="center" bgcolor="ffbbbb" | 6 || April 6 || Diamondbacks || 5–2 <small>(10)</small> || Lyon (1–1) || Bowie (0–1) || Qualls (1) || 42,865 || 1–5 |- align="center" bgcolor="bbffbb" | 7 || April 7 || Braves || 2–1 || Herges (1–0) || Boyer (0–2) || Corpas (2) || 24,304 || 2–5 |- align="center" bgcolor="bbffbb" | 8 || April 8 || Braves || 4–3 || Jiménez (1–1) || Jurrjens (1–1) || Corpas (3) || 24,640 || 3–5 |- align="center" bgcolor="bbffbb" | 9 || April 9 || Braves || 12–6 || Redman (1–1) || James (0–1) || || 23,210 || 4–5 |- align="center" bgcolor="#bbbbbb" | â || April 10 || Braves ||colspan=6|Postponed (snow) <small>Rescheduled for June 16</small> |- align="center" bgcolor="ffbbbb" | 10 || April 11 || @ Diamondbacks || 8–2 || Webb (3–0) || Francis (0–2) || || 31,732 || 4–6 |- align="center" bgcolor="ffbbbb" | 11 || April 12 || @ Diamondbacks || 10–3 || Haren (2–0) || Morales (0–1) || || 29,256 || 4–7 |- align="center" bgcolor="bbffbb" | 12 || April 13 || @ Diamondbacks || 13–5 || Cook (1–1) || González (0–1) || || 31,321 || 5–7 |- align="center" bgcolor="ffbbbb" | 13 || April 15 || @ Padres || 6–0 || Wolf (1–0) || Jiménez (1–2) || || 24,439 || 5–8 |- align="center" bgcolor="bbffbb" | 14 || April 16 || @ Padres || 10–2 || Redman (2–1) || Germano (0–1) || || 21,730 || 6–8 |- align="center" bgcolor="bbffbb" | 15 || April 17 || @ Padres || 2–1 <small>(22)</small> || Wells (1–0) || Rusch (0–1) || || 25,984 || 7–8 |- align="center" bgcolor="bbffbb" | 16 || April 18 || @ Astros || 11–5 || Morales (1–1) || Sampson (0–2) || || 34,272 || 8–8 |- align="center" bgcolor="bbffbb" | 17 || April 19 || @ Astros || 3–2 || Cook (2–1) || Villarreal (0–3) || Corpas (4) || 34,540 || 9–8 |- align="center" bgcolor="ffbbbb" | 18 || April 20 || @ Astros || 6–4 || Wright (2–0) || Fuentes (0–1) || Valverde (2) || 35,286 || 9–9 |- align="center" bgcolor="ffbbbb" | 19 || April 21 || Phillies || 9–5 || Seánez (2–1) || Buchholz (1–1) || || 24,886 || 9–10 |- align="center" bgcolor="ffbbbb" | 20 || April 22 || Phillies || 8–6 || Madson (1–0) || Corpas (0–1) || Lidge (4) || 26,665 || 9–11 |- align="center" bgcolor="ffbbbb" | 21 || April 23 || Cubs || 7–6 <small>(10)</small> || Wood (2–0) || Wells (1–1) || Mármol (2) || 36,864 || 9–12 |- align="center" bgcolor="bbffbb" | 22 || April 24 || Cubs || 4–2 || Cook (3–1) || Hart (2–1) || Fuentes (1) || 32,791 || 10–12 |- align="center" bgcolor="ffbbbb" | 23 || April 25 || @ Dodgers || 8–7 <small>(13)</small> || Park (1–0) || Buchholz (1–2) || || 53,205 || 10–13 |- align="center" bgcolor="ffbbbb" | 24 || April 26 || @ Dodgers || 11–3 || Penny (4–2) || Redman (2–2) || || 50,469 || 10–14 |- align="center" bgcolor="ffbbbb" | 25 || April 27 || @ Dodgers || 3–2 <small>(10)</small> || Beimel (1–0) || Corpas (0–2) || || 50,670 || 10–15 |- align="center" bgcolor="ffbbbb" | 26 || April 28 || @ Giants || 4–0 || Cain (1–2) || Morales (1–2) || || 30,153 || 10–16 |- align="center" bgcolor="bbffbb" | 27 || April 29 || @ Giants || 3–2 || Cook (4–1) || Lincecum (4–1) || Fuentes (2) || 32,176 || 11–16 |- align="center" bgcolor="ffbbbb" | 28 || April 30 || @ Giants || 3–2 || Valdéz (1–0) || Speier (0–1) || Wilson (9) || 30,509 || 11–17 |-
|- align="center" bgcolor="ffbbbb" | 29 || May 2 || Dodgers || 11–6 || Penny (5–2) || Francis (0–3) || || 30,291 || 11–18 |- align="center" bgcolor="ffbbbb" | 30 || May 3 || Dodgers || 12–7 || Kuo (1–1) || de la Rosa (0–1) || || 38,597 || 11–19 |- align="center" bgcolor="bbffbb" | 31 || May 4 || Dodgers || 7–2 || Cook (5–1) || Lowe (2–2) || Buchholz (1) || 43,726 || 12–19 |- align="center" bgcolor="ffbbbb" | 32 || May 5 || Cardinals || 6–5 || Flores (1–0) || Fuentes (0–2) || Isringhausen (11) || 28,183 || 12–20 |- align="center" bgcolor="ffbbbb" | 33 || May 6 || Cardinals || 6–5 || Looper (5–1) || Redman (2–3) || Franklin (1) || 25,460 || 12–21 |- align="center" bgcolor="bbffbb" | 34 || May 7 || Cardinals || 4–3 || Speier (1–1) || Isringhausen (1–3) || Fuentes (3) || 25,432 || 13–21 |- align="center" bgcolor="bbffbb" | 35 || May 8 || Cardinals || 9–3 || de la Rosa (1–1) || Lohse (3–2) || || 25,376 || 14–21 |- align="center" bgcolor="bbffbb" | 36 || May 9 || @ Padres || 4–2 || Cook (6–1) || Peavy (4–2) || Fuentes (4) || 31,057 || 15–21 |- align="center" bgcolor="ffbbbb" | 37 || May 10 || @ Padres || 3–2 || Maddux (3–3) || Jiménez (1–3) || Hoffman (6) || 34,117 || 15–22 |- align="center" bgcolor="ffbbbb" | 38 || May 11 || @ Padres || 6–1 || Young (3–3) || Reynolds (0–1) || || 28,624 || 15–23 |- align="center" bgcolor="ffbbbb" | 39 || May 13 || @ Diamondbacks || 8–4 || Johnson (3–1) || Francis (0–4) || || 27,292 || 15–24 |- align="center" bgcolor="ffbbbb" | 40 || May 14 || @ Diamondbacks || 4–3 || Owings (5–1) || de la Rosa (1–2) || Lyon (11) || 23,127 || 15–25 |- align="center" bgcolor="ffbbbb" | 41 || May 15 || @ Diamondbacks || 8–5 || Webb (9–0) || Cook (6–2) || Lyon (12) || 21,447 || 15–26 |- align="center" bgcolor="ffbbbb" | 42 || May 16 || Twins || 4–2 || Blackburn (4–2) || Jiménez (1–4) || Nathan (13) || 35,336 || 15–27 |- align="center" bgcolor="bbffbb" | 43 || May 17 || Twins || 3–2 || Herges (2–0) || Hernández (6–2) || Fuentes (5) || 43,149 || 16–27 |- align="center" bgcolor="bbffbb" | 44 || May 18 || Twins || 6–2 || Francis (1–4) || Slowey (0–4) || || 40,326 || 17–27 |- align="center" bgcolor="bbffbb" | 45 || May 19 || Giants || 4–3 || Grilli (1–0) || Chulk (0–3) || Fuentes (6) || 28,362 || 18–27 |- align="center" bgcolor="ffbbbb" | 46 || May 20 || Giants || 6–5 || Lincecum (6–1) || Cook (6–3) || Wilson (13) || 28,361 || 18–28 |- align="center" bgcolor="ffbbbb" | 47 || May 21 || Giants || 3–2 <small>(10)</small> || Walker (2–2) || Herges (2–1) || Wilson (14) || 27,081 || 18–29 |- align="center" bgcolor="bbffbb" | 48 || May 23 || Mets || 6–5 <small>(13)</small> || Buchholz (2–2) || Heilman (0–1) || || 33,341 || 19–29 |- align="center" bgcolor="ffbbbb" | 49 || May 24 || Mets || 9–2 || Vargas (1–2) || Francis (1–5) || || 38,142 || 19–30 |- align="center" bgcolor="bbffbb" | 50 || May 25 || Mets || 4–1 || Cook (7–3) || Maine (5–4) || || 42,123 || 20–30 |- align="center" bgcolor="ffbbbb" | 51 || May 26 || @ Phillies || 20–5 || Moyer (5–3) || de la Rosa (1–3) || || 44,764 || 20–31 |- align="center" bgcolor="ffbbbb" | 52 || May 27 || @ Phillies || 7–4 || Kendrick (4–2) || Jiménez (1–5) || || 34,716 || 20–32 |- align="center" bgcolor="ffbbbb" | 53 || May 28 || @ Phillies || 6–1 || Eaton (1–3) || Reynolds (0–2) || || 39,845 || 20–33 |- align="center" bgcolor="ffbbbb" | 54 || May 29 || @ Cubs || 8–4 || Wuertz (1–1) || Herges (2–2) || || 39,851 || 20–34 |- align="center" bgcolor="ffbbbb" | 55 || May 30 || @ Cubs || 10–9 || Eyre (2–0) || Corpas (0–3) || Wood (13) || 39,686 || 20–35 |- align="center" bgcolor="ffbbbb" | 56 || May 31 || @ Cubs || 5–4 || Dempster (7–2) || Rusch (1–3) || Mármol (3) || 41,529 || 20–36 |-
|- align="center" bgcolor="ffbbbb" | 57 || June 1 || @ Cubs || 5–3 || Gallagher (3–1) || Jiménez (1–6) || Wood (14) || 41,730 || 20–37 |- align="center" bgcolor="ffbbbb" | 58 || June 2 || @ Dodgers || 8–2 || Lowe (3–5) || Reynolds (0–3) || || 39,098 || 20–38 |- align="center" bgcolor="bbffbb" | 59 || June 3 || @ Dodgers || 3–0 || Francis (2–5) || Penny (5–7) || Fuentes (7) || 38,548 || 21–38 |- align="center" bgcolor="bbffbb" | 60 || June 4 || @ Dodgers || 2–1 || Cook (8–3) || Kershaw (0–1) || Fuentes (8) || 36,393 || 22–38 |- align="center" bgcolor="bbffbb" | 61 || June 6 || Brewers || 6–4 || Corpas (1–3) || Mota (2–4) || Fuentes (9) || 30,558 || 23–38 |- align="center" bgcolor="bbffbb" | 62 || June 7 || Brewers || 7–2 || Reynolds (1–3) || Bush (2–6) || || 37,283 || 24–38 |- align="center" bgcolor="ffbbbb" | 63 || June 8 || Brewers || 3–2 || Suppan (4–4) || Francis (2–6) || Torres (7) || 32,256 || 24–39 |- align="center" bgcolor="bbffbb" | 64 || June 10 || Giants || 10–5 || Cook (9–3) || Misch (0–3) || || 28,359 || 25–39 |- align="center" bgcolor="bbffbb" | 65 || June 11 || Giants || 1–0 || Fuentes (1–2) || Yabu (2–3) || || 26,235 || 26–39 |- align="center" bgcolor="ffbbbb" | 66 || June 12 || Giants || 10–7 || Sánchez (6–3) || Reynolds (1–4) || Wilson (19) || 30,376 || 26–40 |- align="center" bgcolor="ffbbbb" | 67 || June 13 || @ White Sox || 5–4 || Thornton (3–1) || Herges (2–3) || Jenks (16) || 30,143 || 26–41 |- align="center" bgcolor="bbffbb" | 68 || June 14 || @ White Sox || 2–0 || Grilli (2–0) || Dotel (3–4) || Fuentes (10) || 35,663 || 27–41 |- align="center" bgcolor="bbffbb" | 69 || June 15 || @ White Sox || 5–3 || Cook (10–3) || Contreras (6–5) || Fuentes (11) || 32,004 || 28–41 |- align="center" bgcolor="ffbbbb" | 70 || June 16 || Braves || 7–1 || Jurrjens (7–3) || Jiménez (1–7) || || 25,120 || 28–42 |- align="center" bgcolor="bbffbb" | 71 || June 17 || Indians || 10–2 || Reynolds (2–4) || Byrd (3–7) || || 28,146 || 29–42 |- align="center" bgcolor="bbffbb" | 72 || June 18 || Indians || 4–2 || Francis (3–6) || Laffey (4–4) || Fuentes (12) || 28,339 || 30–42 |- align="center" bgcolor="bbffbb" | 73 || June 19 || Indians || 6–3 || de la Rosa (2–3) || Sowers (0–2) || Fuentes (13) || 33,174 || 31–42 |- align="center" bgcolor="ffbbbb" | 74 || June 20 || Mets || 7–2 || Maine (7–5) || Cook (10–4) || || 30,411 || 31–43 |- align="center" bgcolor="bbffbb" | 75 || June 21 || Mets || 7–1 || Jiménez (2–7) || MartÃÂnez (2–1) || || 35,637 || 32–43 |- align="center" bgcolor="ffbbbb" | 76 || June 22 || Mets || 3–1 || Pelfrey (4–6) || Reynolds (2–5) || Wagner (17) || 45,019 || 32–44 |- align="center" bgcolor="ffbbbb" | 77 || June 23 || @ Royals || 8–4 || Bannister (7–6) || Francis (3–7) || || 12,260 || 32–45 |- align="center" bgcolor="ffbbbb" | 78 || June 24 || @ Royals || 7–3 || Greinke (7–4) || de la Rosa (2–4) || || 19,169 || 32–46 |- align="center" bgcolor="ffbbbb" | 79 || June 25 || @ Royals || 4–2 || Hochevar (5–5) || Cook (10–5) || Soria (21) || 16,615 || 32–47 |- align="center" bgcolor="ffbbbb" | 80 || June 27 || @ Tigers || 7–1 || Bonine (2–0) || Jiménez (2–8) || || 40,842 || 32–48 |- align="center" bgcolor="ffbbbb" | 81 || June 28 || @ Tigers || 7–6 || Dolsi (1–2) || Fuentes (1–3) || || 42,729 || 32–49 |- align="center" bgcolor="ffbbbb" | 82 || June 29 || @ Tigers || 4–3 || Rogers (6–5) || Reynolds (2–6) || Jones (15) || 41,305 || 32–50 |- align="center" bgcolor="ffbbbb" | 83 || June 30 || Padres || 15–8 || Bell (6–3) || Fuentes (1–4) || || 43,248 || 32–51 |-
|- align="center" bgcolor="bbffbb" | 84 || July 1 || Padres || 4–0 || Cook (11–5) || Banks (2–3) || || 26,221 || 33–51 |- align="center" bgcolor="bbffbb" | 85 || July 2 || Padres || 8–1 || Jiménez (3–8) || Wolf (5–8) || || 28,377 || 34–51 |- align="center" bgcolor="bbffbb" | 86 || July 3 || Marlins || 6–5 <small>(11)</small> || Herges (3–3) || Gregg (6–3) || || 48,084 || 35–51 |- align="center" bgcolor="bbffbb" | 87 || July 4 || Marlins || 18–17 || Buchholz (3–2) || Gregg (6–4) || || 48,691 || 36–51 |- align="center" bgcolor="bbffbb" | 88 || July 5 || Marlins || 12–6 || de la Rosa (3–4) || Tucker (2–3) || || 35,137 || 37–51 |- align="center" bgcolor="ffbbbb" | 89 || July 6 || Marlins || 10–5 || Volstad (1–0) || Cook (11–6) || || 27,168 || 37–52 |- align="center" bgcolor="bbffbb" | 90 || July 7 || @ Brewers || 4–3 || Jiménez (4–8) || McClung (5–4) || Fuentes (14) || 35,161 || 38–52 |- align="center" bgcolor="ffbbbb" | 91 || July 8 || @ Brewers || 7–3 || Sabathia (7–8) || Redman (2–4) || || 42,533 || 38–53 |- align="center" bgcolor="bbffbb" | 92 || July 9 || @ Brewers || 8–3 || Rusch (2–3) || Sheets (10–3) || || 37,092 || 39–53 |- align="center" bgcolor="ffbbbb" | 93 || July 10 || @ Brewers || 11–1 || Bush (5–8) || de la Rosa (3–5) || || 43,389 || 39–54 |- align="center" bgcolor="ffbbbb" | 94 || July 11 || @ Mets || 2–1 || Feliciano (2–2) || Buchholz (3–3) || Wagner (21) || 49,016 || 39–55 |- align="center" bgcolor="ffbbbb" | 95 || July 12 || @ Mets || 3–0 || Muñiz (1–1) || Jiménez (4–9) || Wagner (22) || 54,137 || 39–56 |- align="center" bgcolor="ffbbbb" | 96 || July 13 || @ Mets || 7–0 || Pelfrey (8–6) || Redman (2–5) || || 51,293 || 39–57 |- align="center" bgcolor="bbffbb" | 97 || July 17 || Pirates || 5–3 || Jiménez (5–9) || Maholm (6–6) || Fuentes (15) || 30,584 || 40–57 |- align="center" bgcolor="bbffbb" | 98 || July 18 || Pirates || 5–2 || Rusch (3–3) || Snell (3–8) || Fuentes (16) || 37,114 || 41–57 |- align="center" bgcolor="bbffbb" | 99 || July 19 || Pirates || 7–1 || de la Rosa (4–5) || Herrera (0–1) || || 44,565 || 42–57 |- align="center" bgcolor="bbffbb" | 100 || July 20 || Pirates || 11–3 || Cook (12–6) || Duke (4–7) || || 30,488 || 43–57 |- align="center" bgcolor="ffbbbb" | 101 || July 21 || Dodgers || 16–10 || Falkenborg (2–2) || Wells (1–2) || || 38,291 || 43–58 |- align="center" bgcolor="bbffbb" | 102 || July 22 || Dodgers || 10–1 || Jiménez (6–9) || Kershaw (0–3) || || 41,567 || 44–58 |- align="center" bgcolor="bbffbb" | 103 || July 23 || Dodgers || 5–3 || Rusch (4–3) || Kuroda (5–7) || Fuentes (17) || 36,305 || 45–58 |- align="center" bgcolor="bbffbb" | 104 || July 25 || @ Reds || 7–2 || Cook (13–6) || Vólquez (12–4) || || 27,501 || 46–58 |- align="center" bgcolor="bbffbb" | 105 || July 26 || @ Reds || 5–1 || de la Rosa (5–5) || Bailey (0–4) || || 33,981 || 47–58 |- align="center" bgcolor="bbffbb" | 106 || July 27 || @ Reds || 11–0 || Jiménez (7–9) || Fogg (2–3) || || 28,246 || 48–58 |- align="center" bgcolor="ffbbbb" | 107 || July 28 || @ Pirates || 8–4 || Snell (4–8) || Grilli (2–1) || || 15,303 || 48–59 |- align="center" bgcolor="ffbbbb" | 108 || July 29 || @ Pirates || 6–4 || Davis (1–0) || Herges (3–4) || Yates (1) || 17,507 || 48–60 |- align="center" bgcolor="bbffbb" | 109 || July 30 || @ Pirates || 7–4 || Cook (14–6) || Duke (4–9) || Fuentes (18) || 16,587 || 49–60 |- align="center" bgcolor="ffbbbb" | 110 || July 31 || @ Marlins || 12–2 || Sánchez (1–0) || de la Rosa (5–6) || || 13,634 || 49–61 |-
|- align="center" bgcolor="bbffbb" | 111 || August 1 || @ Marlins || 5–2 || Jiménez (8–9) || Volstad (2–2) || Fuentes (19) || 16,555 || 50–61 |- align="center" bgcolor="ffbbbb" | 112 || August 2 || @ Marlins || 5–3 || Nolasco (11–6) || De Los Santos (0–1) || Gregg (24) || 22,324 || 50–62 |- align="center" bgcolor="bbffbb" | 113 || August 3 || @ Marlins || 3–2 || Buchholz (4–3) || Nelson (2–1) || Fuentes (20) || 14,310 || 51–62 |- align="center" bgcolor="ffbbbb" | 114 || August 4 || Nationals || 9–4 || Redding (8–6) || Cook (14–7) || || 33,143 || 51–63 |- align="center" bgcolor="bbffbb" | 115 || August 5 || Nationals || 8–2 || Corpas (2–3) || Ayala (1–7) || || 27,483 || 52–63 |- align="center" bgcolor="#bbbbbb" | â || August 6 || Nationals ||colspan=6|Postponed (rain) <small>Rescheduled for August 7</small> |- align="center" bgcolor="ffbbbb" | 116 || August 7 || Nationals || 6–3 || Bergmann (2–8) || Francis (3–8) || Hanrahan (2) || || 52–64 |- align="center" bgcolor="ffbbbb" | 117 || August 7 || Nationals || 6–3 || Pérez (5–8) || Jiménez (8–10) || Hanrahan (3) || 30,448 || 52–65 |- align="center" bgcolor="bbffbb" | 118 || August 8 || Padres || 6–3 || Rusch (5–3) || Peavy (8–8) || Fuentes (21) || 33,147 || 53–65 |- align="center" bgcolor="ffbbbb" | 119 || August 9 || Padres || 8–3 || Maddux (6–8) || Cook (14–8) || Hoffman (25) || 41,640 || 53–66 |- align="center" bgcolor="ffbbbb" | 120 || August 10 || Padres || 16–7 || Hampson (1–1) || Hernández (10–9) || || 45,660 || 53–67 |- align="center" bgcolor="ffbbbb" | 121 || August 12 || Diamondbacks || 4–2 || Johnson (10–8) || Jiménez (8–11) || Lyon (25) || 31,218 || 53–68 |- align="center" bgcolor="bbffbb" | 122 || August 13 || Diamondbacks || 6–5 || Buchholz (5–3) || Rauch (4–3) || Fuentes (22) || 30,247 || 54–68 |- align="center" bgcolor="ffbbbb" | 123 || August 14 || Diamondbacks || 6–2 || Haren (13–6) || Rusch (5–4) || || 27,575 || 54–69 |- align="center" bgcolor="bbffbb" | 124 || August 15 || @ Nationals || 4–3 || de la Rosa (6–6) || Redding (8–8) || Fuentes (23) || 27,965 || 55–69 |- align="center" bgcolor="bbffbb" | 125 || August 16 || @ Nationals || 13–6 || Hernández (11–9) || Lannan (6–12) || || 28,909 || 56–69 |- align="center" bgcolor="bbffbb" | 126 || August 17 || @ Nationals || 7–2 || Cook (15–8) || Pérez (5–9) || || 31,467 || 57–69 |- align="center" bgcolor="bbffbb" | 127 || August 19 || @ Dodgers || 8–3 || Jiménez (9–11) || Kuroda (7–9) || || 46,687 || 58–69 |- align="center" bgcolor="bbffbb" | 128 || August 20 || @ Dodgers || 4–3 || Buchholz (6–3) || Broxton (3–5) || Fuentes (24) || 48,183 || 59–69 |- align="center" bgcolor="ffbbbb" | 129 || August 21 || @ Dodgers || 3–1 || Lowe (10–10) || de la Rosa (6–7) || Broxton (10) || 44,885 || 59–70 |- align="center" bgcolor="ffbbbb" | 130 || August 22 || Reds || 8–5 || Harang (4–13) || Hernández (11–10) || Cordero (25) || 30,337 || 59–71 |- align="center" bgcolor="bbffbb" | 131 || August 23 || Reds || 7–6 || VizcaÃÂno (1–0) || Lincoln (1–4) || Fuentes (25) || 42,282 || 60–71 |- align="center" bgcolor="bbffbb" | 132 || August 24 || Reds || 4–3 <small>(12)</small> || Speier (2–1) || Lincoln (1–5) || || 31,173 || 61–71 |- align="center" bgcolor="bbffbb" | 133 || August 25 || @ Giants || 4–2 || Francis (4–8) || Cain (8–10) || Fuentes (26) || 31,132 || 62–71 |- align="center" bgcolor="bbffbb" | 134 || August 26 || @ Giants || 7–2 || de la Rosa (7–7) || Palmer (0–2) || Grilli (1) || 32,695 || 63–71 |- align="center" bgcolor="ffbbbb" | 135 || August 27 || @ Giants || 4–1 || Lincecum (15–3) || Hernández (11–11) || Wilson (36) || 31,627 || 63–72 |- align="center" bgcolor="bbffbb" | 136 || August 29 || @ Padres || 9–4 || Cook (16–8) || Hayhurst (0–1) || || 25,274 || 64–72 |- align="center" bgcolor="ffbbbb" | 137 || August 30 || @ Padres || 9–4 || Geer (1–0) || Jiménez (9–12) || || 30,240 || 64–73 |- align="center" bgcolor="ffbbbb" | 138 || August 31 || @ Padres || 2–1 || Hoffman (3–6) || Buchholz (6–4) || || 26,395 || 64–74 |-
|- align="center" bgcolor="bbffbb" | 139 || September 1 || Giants || 4–0 || de la Rosa (8–7) || Sánchez (8–10) || || 31,388 || 65–74 |- align="center" bgcolor="bbffbb" | 140 || September 2 || Giants || 6–5 <small>(12)</small> || Grilli (3–1) || Yabu (3–6) || || 23,710 || 66–74 |- align="center" bgcolor="ffbbbb" | 141 || September 3 || Giants || 9–2 || Zito (9–16) || Cook (16–9) || || 23,481 || 66–75 |- align="center" bgcolor="bbffbb" | 142 || September 5 || Astros || 5–3 || Jiménez (10–12) || Moehler (10–6) || Fuentes (27) || 26,163 || 67–75 |- align="center" bgcolor="ffbbbb" | 143 || September 6 || Astros || 2–0 || Oswalt (14–9) || Francis (4–9) || || 32,352 || 67–76 |- align="center" bgcolor="ffbbbb" | 144 || September 7 || Astros || 7–5 || Brocail (7–5) || Buchholz (6–5) || Valverde (40) || 30,509 || 67–77 |- align="center" bgcolor="ffbbbb" | 145 || September 9 || @ Braves || 5–4 <small>(10)</small> || Tavárez (1–2) || Buchholz (6–6) || || 21,821 || 67–78 |- align="center" bgcolor="ffbbbb" | 146 || September 10 || @ Braves || 9–5 || Bennett (3–6) || VizcaÃÂno (1–1) || || 19,693 || 67–79 |- align="center" bgcolor="ffbbbb" | 147 || September 11 || @ Braves || 8–4 || Jurrjens (13–9) || Rusch (5–5) || || 20,039 || 67–80 |- align="center" bgcolor="ffbbbb" | 148 || September 12 || Dodgers || 7–2 || Billingsley (15–10) || Francis (4–10) || || 30,147 || 67–81 |- align="center" bgcolor="ffbbbb" | 149 || September 13 || Dodgers || 5–1 || Kershaw (4–5) || de la Rosa (8–8) || || 40,291 || 67–82 |- align="center" bgcolor="bbffbb" | 150 || September 14 || Dodgers || 1–0 <small>(10)</small> || Corpas (3–3) || Kuo (5–3) || || 28,910 || 68–82 |- align="center" bgcolor="ffbbbb" | 151 || September 15 || Padres || 11–5 || LeBlanc (1–1) || Reynolds (2–7) || || 25,296 || 68–83 |- align="center" bgcolor="bbffbb" | 152 || September 16 || Padres || 10–3 || Jiménez (11–12) || Estes (2–3) || || 25,507 || 69–83 |- align="center" bgcolor="bbffbb" | 153 || September 17 || Padres || 1–0 || Hernández (12–11) || Geer (2–1) || Fuentes (28) || 25,155 || 70–83 |- align="center" bgcolor="bbffbb" | 154 || September 19 || Diamondbacks || 3–2 || de la Rosa (9–8) || Scherzer (0–3) || Fuentes (29) || 43,137 || 71–83 |- align="center" bgcolor="ffbbbb" | 155 || September 20 || Diamondbacks || 5–3 || Peña (3–2) || Fuentes (1–5) || Qualls (6) || 38,283 || 71–84 |- align="center" bgcolor="ffbbbb" | 156 || September 21 || Diamondbacks || 13–4 || Haren (16–8) || Reynolds (2–8) || || 32,915 || 71–85 |- align="center" bgcolor="bbffbb" | 157 || September 23 || @ Giants || 9–4 || Jiménez (12–12) || Lincecum (17–5) || || 33,922 || 72–85 |- align="center" bgcolor="bbffbb" | 158 || September 24 || @ Giants || 15–6 || Hernández (13–11) || Sánchez (9–12) || || 31,942 || 73–85 |- align="center" bgcolor="bbffbb" | 159 || September 25 || @ Giants || 3–1 || de la Rosa (10–8) || Zito (10–17) || Fuentes (30) || 31,857 || 74–85 |- align="center" bgcolor="ffbbbb" | 160 || September 26 || @ Diamondbacks || 6–4 || Cruz (4–0) || Grilli (3–2) || Qualls (8) || 34,590 || 74–86 |- align="center" bgcolor="ffbbbb" | 161 || September 27 || @ Diamondbacks || 6–4 || Lyon (3–5) || Corpas (3–4) || Qualls (9) || 33,234 || 74–87 |- align="center" bgcolor="ffbbbb" | 162 || September 28 || @ Diamondbacks || 2–1 || Johnson (11–10) || VizcaÃÂno (1–2) || || 35,908 || 74–88 |-
Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in
Note: G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in
Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts
Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts
Note: G = Games pitched; W = Wins; L = Losses; SV = Saves; ERA = Earned run average; SO = Strikeouts