The 2006 Cork Senior Football Championship was the 118th staging of the Cork Senior Football Championship since its establishment by the Cork County Board in 1887. The draw for the opening fixtures took place on 11 December 2005. The championship began on 8 April 2006 and ended on 29 October 2006.
Nemo Rangers entered the championship as the defending champions. Mallow and St Michael's became the first two teams to be officially relegated from the championship.
On 29 October 2006, Nemo Rangers won the championship following a 1-11 to 0-07 defeat of Dohenys in the final. This was their 15th championship title overall, and their second title in succession.
Nemo's James Masters was the championship's top scorer with 2-40.
Promoted from the Cork Intermediate Football Championship