The 2006 1000km of Spa was the second automobile endurance race for Le Mans Prototype and Le Mans Grand Touring cars of the 2006 Le Mans Series season run by the ACO. It was run on May 14, 2006, at the Circuit de Spa-Francorchamps in Belgium.
Pole position winners in each class are marked in bold.
Class winners in bold. Cars failing to complete 70% of winner's distance marked as Not Classified (NC).