The 2000 United States House of Representatives election in South Dakota took place on Tuesday, November 7, 2000, with a primary election on June 6. Voters selected a representative for their single at-large district, who ran on a statewide ballot. Incumbent Republican representative John Thune won the race by a wide margin, outrunning the Republican candidate for president George W. Bush by 13 points in the state.
No Republican primary was held.
Curt Hohn won the three-way Democratic primary with 56.07% of the vote. Only 13.09% of the Democratic electorate turned out to vote in the primary.
No Libertarian primary was held.