2-Methoxyphenethylamine (2-MPEA) is a drug of the phenethylamine family. It is one of the methoxyphenethylamine positional isomers.
The effects of 2-MPEA in humans have not been reported and are unknown.
The drug showed very low affinity for the serotonin receptors in the rat stomach fundus strip (A<sub>2</sub> = 3,020nM). In another study, it showed no affinity for the serotonin 5-HT<sub>2A</sub> or 5-HT<sub>2C</sub> receptors (K<sub>i</sub> = >10,000nM). 2-MPEA is a potent full agonist of the human trace amine-associated receptor 1 (TAAR1) ( = 144nM; = 95%).
2-MPEA was first described in the scientific literature by at least 1943. It was included as an entry in Alexander Shulgin's 2011 book '.