2-Thioisomescaline (2-TIM), also known as 2-methylthio-3,4-dimethoxyphenethylamine, is a chemical compound of the phenethylamine and scaline families related to mescaline. It is the analogue of isomescaline in which the methoxy group at the 2 position has been replaced with a methylthio group. The compound is one of two possible thioisomescaline (TIM) positional isomers, the others being 3-thioisomescaline (3-TIM) and 4-thioisomescaline (4-TIM).
In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 2-TIM's dose as greater than 240mg orally and its duration as unknown. At a dose of 160mg orally, there was some brief possible awareness. In addition, a small amount of alcohol later that day was quite intoxicating. On the other hand, there were no effects whatsoever at a higher dose of 240mg orally. Shulgin concluded that 2-TIM is inactive.
The chemical synthesis of 2-TIM has been described.
2-TIM was first described in the scientific literature by Shulgin and Peyton Jacob III in 1981. Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.