In enzymology, 2-coumarate reductase or melilotate dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 2-hydroxybenzenepropanoic acid (melilotic acid) and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are 2-coumaric acid, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase. This enzyme participates in phenylalanine metabolism.