2,6-Dimethoxyphenethylamine (2,6-DMPEA), also known as DMPEA-5, is a drug of the phenethylamine family related to the psychedelic drug mescaline (3,4,5-trimethoxyphenethylamine). It is one of the positional isomers of dimethoxyphenethylamine.
Its in-vitro metabolism and effects on cat behavior have been described. The drug showed no activity as a norepinephrine reuptake inhibitor or releasing agent in vitro. It is relatively unaffected by monoamine oxidase (MAO) and is said to be behaviorally inactive in animals. The effects of 2,6-DMPEA in humans have not been reported and are unknown.
2,6-DMPEA was first described in the scientific literature by at least 1962. It was included as an entry in Alexander Shulgin's 2011 book '.
Notable derivatives of 2,6-DMPEA include the psychedelic and related drugs è-2C-T-4 (psi-2C-T-4), ÃÂ-DOM (psi-DOM), and CT-5172.