2,4-Dimethoxyphenethylamine (2,4-DMPEA), also known as DMPEA-3, is a drug of the phenethylamine family related to the psychedelic drug mescaline (3,4,5-trimethoxyphenethylamine). It is one of the positional isomers of dimethoxyphenethylamine.
The in-vitro metabolism of 2,3-DMPEA and its effects on cat behavior have been studied. The drug is known to act as a low-potency partial agonist of the serotonin 5-HT<sub>2A</sub> receptor (K<sub>i</sub> = 202âÂÂ999nM; = 832âÂÂ4,034nM; = 67âÂÂ83%). The effects of 2,4-DMPEA in humans have not been reported and are unknown.
2,4-DMPEA was first described in the scientific literature by at least 1964. It was included as an entry in Alexander Shulgin's 2011 book '.
NBOMe and NBOH derivatives with potent serotonin 5-HT<sub>2A</sub> receptor agonism, such as 24-NBOMe and 24-NBOH, have been synthesized and studied.