2,4,6-Tri-tert-butylpyrimidine is the organic compound with the formula HC(Bu<sup>t</sup>C)<sub>2</sub>N<sub>2</sub>C<sup>t</sup>Bu where <sup>t</sup>Bu = (CH<sub>3</sub>)<sub>3</sub>C. It is a substituted derivative of the heterocycle pyrimidine. Known also as TTBP, this compound is of interest as a base that is sufficiently bulky to not bind boron trifluoride but still able to bind protons. It is less expensive that the related bulky derivatives of pyridine such as 2,6-di-tert-butylpyridine, 2,4,6-tri-tert-butylpyridine, and 2,6-di-tert-butyl-4-methylpyridine.