2,4'-dihydroxyacetophenone dioxygenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 2,4'-dihydroxyacetophenone and oxygen. Its products are 4-hydroxybenzoic acid and formic acid.
This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O<sub>2</sub> as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O<sub>2</sub>. The systematic name of this enzyme class is 2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving). This enzyme is also called (4-hydroxybenzoyl)methanol oxygenase. This enzyme participates in bisphenol a degradation.