1V-LSD, also known as 1-valeryl-LSD or by the nickname Valerie, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is an analogue of LSD and is thought to act as a prodrug of LSD. The drug has been encountered as a novel designer recreational drug.
1V-LSD has been sold in the form of blotter containing 150üg per tab. Its effects are said to be comparable to 100 to 120üg 1P-LSD or 1cP-LSD, but with a longer duration. On the other hand, other sources report that 1V-LSD has a shorter duration than LSD of 6 to 8hours.
As demonstrated with other N-acylated derivatives of LSD, 1V-LSD is believed to serve as a prodrug for LSD but may also act directly as a weak partial agonist at the serotonin 5-HT<sub>2A</sub> receptor.
A head-twitch response assay in mice found that 1V-LSD has a similar potency to 1P-LSD and 1cP-LSD, with behavioral effects also closely resembling these structural analogs.
1V-LSD is the condensation product of valeric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of the indole moiety.
Ehrlich's reagent is used to identify the presence of an indole moiety; the chemical backbone of the lysergamide and ergoline molecules. However, as with other N-acylated lysergamides, 1V-LSD reacts very slowly to Ehrlich reagent and may not give reliable results if the reagent isn't fresh.
Related compounds include 1B-LSD, 1cP-LSD, 1D-LSD, 1P-LSD, and AL-LAD, among others.
1V-LSD was first described in the scientific literature by 2022.
1V-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025.
An amendment to the NpSG banned the sale of 1V-LSD in Germany in September 2022. Due to a interpunctation error in the actualised NpSG, the ban never took effect. The law was amended in March 2023, now banning 1V-LSD.
1V-LSD was placed under legal control in South Korea in July 2022 on a temporary but renewable basis.
Since 2 March 2022, 1V-LSD has been under investigation in Sweden and may therefore soon become controlled.
1V-LSD is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.