The 1999 Kilkenny Senior Hurling Championship was the 105th staging of the Kilkenny Senior Hurling Championship since its establishment by the Kilkenny County Board. The draw for the opening round fixtures took place on 12 July 1999. The championship began on 21 August 1999 and ended on 24 October 1999.
Graigue-Ballycallan were the defending champions.
On 24 October 1999, Glenmore won the title after a 1âÂÂ14 to 2âÂÂ08 defeat of Graigue-Ballycallan in the final at Nowlan Park. It was their fifth championship title overall and their first title in four championship seasons. It remains their last championship triumph.
Promoted from the Kilkenny Intermediate Hurling Championship
Relegated to the Kilkenny Intermediate Hurling Championship