The 1999 International League season took place from April to September 1999.
The Charlotte Knights defeated the Durham Bulls to win the league championship.
The North Division Scranton Red Barons (78-66) faced the IL Wild Card the Charlotte Knights (82-62). Charlotte defeated Scranton.
The South Division Champion Durham Bulls (83-60) faced the West Division Champion Columbus Clippers (83-58). Durham defeated Columbus.
Charlotte defeated Durham 3 games to 1.
Charlotte faced the PCL Champions the (Vancouver Canadians) from the Pacific Coast League in the Triple-A World Series. Vancouver won the Series 3 games to 2.