The 1994 United States Senate election in Maine was held November 8, 1994. Incumbent Democratic U.S. Senator and Senate Majority Leader George J. Mitchell decided to retire, instead of seeking a third term. Congressman Tom Andrews won the Democratic primary unopposed, while Congresswoman Olympia Snowe won the Republican primary unopposed.
In the general election, Snowe defeated Andrews in a rout to win her first of three terms in the United States Senate, a stark contrast to retiring Senator Mitchell's landslide win six years prior. Republicans won this seat for the first time since 1952.