The 1991 Cleveland Indians season was the 91st season for the franchise. The Indians lost 105 games, the most losses in franchise history.
On May 4, 1991, Chris James had 9 RBIs in a 20 to 6 win over the Oakland Athletics to set the single game RBI record for Cleveland.
This is to date the most recent season the Indians have finished last in their division.
|- style="text-align:center;" | Legend: = Win = Loss = Postponement<br>Bold = Indians team member
Note: G = Games played; AB = At bats; R = Runs scored; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; AVG = Batting average; SB = Stolen bases
Note: W = Wins; L = Losses; ERA = Earned run average; G = Games pitched; GS = Games started; SV = Saves; IP = Innings pitched; H = Hits allowed; R = Runs allowed; ER = Earned runs allowed; BB = Walks allowed; K = Strikeouts
<small>LEAGUE CHAMPIONS: Kinston</small>