The 1981 NCAA Division II basketball tournament involved 32 schools playing in a single-elimination tournament to determine the national champion of men's NCAA Division II college basketball as a culmination of the 1980âÂÂ81 NCAA Division II men's basketball season. It was won by Florida Southern College and Florida Southern's John Ebeling was the Most Outstanding Player.
<nowiki>*</nowiki>denotes tie
Location: Memorial Gym Host: Mount Saint Mary's College and Seminary
Location: Western Hall Host: Western Illinois University
Location: Brown County Veterans Memorial Arena Host: University of Wisconsin at Green Bay
Location: Flowers Hall Host: University of North Alabama
Location: Alterowitz Gym Host: Eastern Montana College
Location: UCF Fieldhouse Host: University of Central Florida
Location: William T. Boylan Gymnasium Host: Monmouth College
Location: NHC Fieldhouse Host: New Hampshire College
<nowiki>*</nowiki>denotes each overtime played
Location: Springfield Civic Center Hosts: American International College and Springfield College
<nowiki>*</nowiki>denotes each overtime played