The 1981 Campeonato Profesional was the thirty-fourth season of Colombia's top-flight football league. Junior won the league for the fourth time after winning the Cuadrangular final.
Group A
Group B
The overall standings combining results from both the Torneo Apertura and Torneo Finalización determined the remaining qualifiers for the semi-final quadrangulars.
Group A
Group B
The Copa Colombia was played as an additional part of the league championship. Draws were decided by penalty shoot-out, with winners obtaining 2 points and losers none.
The six clubs that had not qualified for the Cuadrangulares played a round-robin tournament. Independiente MedellÃÂn advanced to the final as winners.
The four clubs eliminated in the Cuadrangulares played a round-robin tournament. Deportivo Cali advanced to the final as winners.