The 1980 Tooth Cup was the 7th edition of the NSWRFL Midweek Cup, a NSWRFL-organised national club Rugby League tournament between the leading clubs and representative teams from the NSWRFL, the BRL, the CRL, the QRL and the NZRL.
A total of 16 teams from across Australia and New Zealand played 23 matches in a round-robin format with teams playing 2 games each with the top 8 teams advanced to a knockout stage, with the matches being held midweek during the premiership season.