General elections were held in Palau on 4 November 1980 to elect a president, vice-president, Senate and House of Delegates. All candidates ran as independents. Haruo Remeliik won the election for president with 31.2% of the vote, whilst Alfonso Oiterong was elected vice-president. Voter turnout was 80%.
Following the elections, Haruo Remeliik and Alfonso Oiterong were sworn in as president and vice president on 1 January 1981. Kaleb Udui was elected president of the Senate, with Carlos Salii elected Speaker of the House of Delegates.