The 1972 United States Senate election in Wyoming was held on November 7, 1972. Incumbent Republican Senator Clifford Hansen ran for re-election to a second term. He was challenged by Democratic nominee Mike Vinich, a former aide to Congressman Teno Roncalio and a bar owner in Hudson. As Hansen ran for re-election, President Richard Nixon was overwhelmingly defeating Democratic presidential nominee George McGovern in Wyoming. Hansen managed to outperform even Nixon, winning his second term in a landslide over Vinich.