The 1966 United States Senate election in Kansas took place on November 8, 1966, concurrently with elections to the United States Senate in other states as well as elections to the United States House of Representatives and various state and local elections.
Incumbent Republican U.S. Senator James B. Pearson defeated Democratic nominee James Floyd Breeding with 52.15% of the vote.
Primary elections were held on August 2, 1966.