The 1959 Saint Louis Billikens men's soccer team represented Saint Louis University during the 1959 NCAA soccer season. The Billikens won the first ever national title this season. It was the second ever season the Billikens fielded a men's varsity soccer team, and it is considered by many American soccer historians to be the start of a dynasty.
|- !colspan=6 style=""| Regular season |-
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|- !colspan=6 style=""| <span style="color:#FFFFFF;">NCAA Tournament</span> |-
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