The 1958 United States Senate election in Wyoming took place November 4, 1958. Incumbent Republican Senator Frank A. Barrett ran for re-election to his second term. He was challenged by Gale W. McGee, a University of Wyoming professor and the Democratic nominee. Despite the state's strong Republican lean, McGee ran an energetic campaign against Barrett, earning the support of the national Democratic establishment. McGee ultimately narrowly upset Barrett, winning 51% of the vote to Barrett's 49%.