The 1958 United States Senate election in Pennsylvania was held on November 4, 1958. Incumbent Republican U.S. Senator Edward Martin did not seek re-election. The Republican nominee, Hugh Scott, defeated Democratic nominee George M. Leader for the vacant seat.
As of , this is the last Senate election where Fulton County voted Democratic.
|- |-bgcolor="#EEEEEE" | colspan="3" align="right" | Totals | align="right" | 3,988,622 | align="right" | 100.00% | align="right" |