The 1958 United States Senate election in Michigan was held on November 4, 1958.
Incumbent Senator Charles E. Potter was defeated in his bid for re-election to a second term by Lieutenant Governor Philip A. Hart. This was one of a record 15 seats Democrats gained from the Republican Party. This was the first time since 1857 that Democrats held both Senate seats in the state simultaneously.
Senator Potter was unopposed for re-nomination by the Republican Party.