The 1950 United States House of Representatives elections in South Carolina were held on November 7, 1950, to select six Representatives for two-year terms from the state of South Carolina. Four incumbents were re-elected, but Hugo S. Sims, Jr. of the 2nd congressional district and James Butler Hare of the 3rd congressional district were defeated in the Democratic primaries. The seats were retained by the Democrats and the composition of the state delegation remained solely Democratic.
Incumbent Democratic Congressman L. Mendel Rivers of the 1st congressional district, in office since 1941, defeated A.J. Clement in the Democratic primary and was unopposed in the general election.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congressman Hugo S. Sims, Jr. of the 2nd congressional district, in office since 1949, was defeated in the Democratic primary by John J. Riley who was unopposed in the general election.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congressman James Butler Hare of the 3rd congressional district, in office since 1949, was defeated in the Democratic primary by W.J. Bryan Dorn who was unopposed in the general election.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congressman Joseph R. Bryson of the 4th congressional district, in office since 1939, defeated Matthew Poliakoff in the Democratic primary and was unopposed in the general election.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congressman James P. Richards of the 5th congressional district, in office since 1933, was unopposed in his bid for re-election.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congressman John L. McMillan of the 6th congressional district, in office since 1939, was unopposed in his bid for re-election.
|- | | colspan=5 |Democratic hold |-