The 1950 Oklahoma gubernatorial election was held on November 7, 1950, and was a race for Governor of Oklahoma. Democrat Johnston Murray defeated Republican Jo O. Ferguson. Phil Ferguson unsuccessfully sought the Democratic nomination.
Johnston Murray, the son of former governor William H. Murray, defeated William O. Coe by a razor-thin margin of 960 votes in a runoff.
Jo Ferguson was the first Republican to win Cleveland County in a gubernatorial election. By flipping to Murray after voting Republican in the previous two elections, Rogers County began a streak of voting for the winning candidate that currently remains unbroken and is the longest active bellwether streak in state gubernatorial elections.