The 1948 United States Senate election in Colorado took place on November 2, 1948. Incumbent Democratic Senator Edwin C. Johnson was re-elected to third term in a landslide over Republican Will Nicholson, a businessman and Air Force veteran, winning every county in the state.
Johnson outperformed fellow Democrat Harry S. Truman in the concurrent presidential election by 29%. As of 2023, this is the last time that an incumbent Democratic Senator from Colorado was re-elected or won re-election for this seat.