The 1948 United States House of Representatives election in Wyoming was held on November 2, 1948. Incumbent Republican Congressman Frank A. Barrett ran for re-election to a fourth term. He was challenged by Democratic nominee Pat Flannery, an aide to U.S. Senator Joseph C. O'Mahoney. As President Harry S. Truman won the state in the presidential election, Barrett narrowly won re-election, defeating Flannery with 52 percent of the vote.