The 1946 United States Senate election in North Dakota took place on November 5, 1946. Incumbent Republican Senator William Langer ran for re-election to a second term. Langer defeated State Senator Joseph Bridston in the Republican primary, who challenged Langer over his isolationist views. In the general election, he was opposed by Abner Larson, the Democratic nominee, and former State Superintendent of Public Instruction Arthur E. Thompson, who ran as an independent. Langer easily defeated both candidates and won re-election in a landslide.