The 1946 United States Senate election in Minnesota took place on November 5, 1946. It was the first election to either of Minnesota's seats in the United States Senate held since the Minnesota Democratic Party and the Farmer-Labor Party of Minnesota merged in 1944, to form the Minnesota Democratic-Farmer-Labor Party. Incumbent U.S. Senator Henrik Shipstead was defeated in the Republican primary by Governor Edward John Thye, who went on to defeat DFL challenger Theodore Jorgenson in the general election.