The 1945 Campeonato Paulista da Primeira Divisão, organized by the Federação Paulista de Futebol, was the 44th season of São Paulo's top professional football league. São Paulo won the title for the 3rd time. No teams were relegated. The top scorers were Corinthians's ServÃÂlio and São Paulo Railway's Passarinho, each with 17 goals.
The championship was disputed in a double-round robin system, with the team with the most points winning the title.