The 1944 United States Senate election in Kansas was held on November 7, 1944. Incumbent Republican Senator Clyde M. Reed ran for re-election to a second term. He was initially challenged by former Senator George McGill, whom he had defeated in 1938. However, after winning the Democratic nomination, McGill withdrew from the race to accept an appointment to the U.S. Tariff Commission. McGill was replaced as the Democratic nominee by Thurman Hill, an Independence attorney and former Public Service Commissioner. Reed defeated Hill in a landslide as Republican presidential nominee Thomas E. Dewey handily won the state over President Franklin D. Roosevelt.
After McGill won the primary, he withdrew from the race upon his nomination to the U.S. Tariff Commission. He was replaced as the Democratic nominee by Thurman Hill, an attorney from Independence, former member of the Kansas Public Service Commission, and counsel to the U.S. Department of the Treasury.