The 27th edition of the Tour of Flanders cycling classic race was held on Sunday, 19 April 1943. Belgian Achiel Buysse won the Monument for a third time. In total, 37 of 126 riders finished.
The race started in Ghent and finished there, in the Kuipke velodrome, totalling 215 km (133 miles).
The course featured 3 categorized climbs:
Achiel Buysse won in the sprint ahead of his two breakaway companions in Ghent, Albert Sercu and Camille Beeckman. Buysse completed the race with an average of 35,05 km/h.