The 1942 Syracuse Orangemen football team represented Syracuse University in the 1942 college football season. The Orangemen were led by sixth-year head coach Ossie Solem.
Syracuse was ranked at No. 72 (out of 590 college and military teams) in the final rankings under the Litkenhous Difference by Score System for 1942.
The team played its home games at Archbold Stadium in Syracuse, New York.